Endocrine Abstracts

Background: Adamantinomatous craniopharyngiomas (ACPs) are rare, benign, epithelial tumours of the sellar-suprasellar region. Craniopharyngiomas cause considerable morbidity and mortality due to local invasion and treatment-related damage to surrounding structures, including the hypothalamus and pituitary gland, leading to hypopituitarism and diabetes insipidus (DI). Trametinib is a highly selective mitogen-activated protein kinase (MEK) inhibitor, which has been recently used...

Background: Falls in the elderly are a major public health burden as more than one in three people over 65 years falls per annum. Vitamin D deficiency is common in the elderly due to decreased sunlight exposure, dietary vitamin D intake and efficiency of cutaneous vitamin D production. Vitamin D deficiency causes myopathy, impaired psychomotor function and increased sway thus increasing the risk of falls, whilst supplementation decreases falls. We hypothesized that vitamin D d...

Background and Methods: PCOS is common and associated with significant comorbidity. Yet, its pathogenesis is complex and poorly understood. We have developed new methods for deep phenotyping discovery proteomic profiling of urine to identify disease mechanisms and novel non-invasive biomarkers for PCOS in adolescents. We undertook proteomic analysis (nano 2D-LC-QTOF MSe) on a subset of 15 samples from a longitudinal PCOS cohort of 40 participants. We compared the ur...

Introduction: In children, BRAF (e.g. dabrafenib) and MEK (e.g. trametinib) inhibitors are used to treat a range of tumours including low-grade gliomas, Langerhans cell histiocytosis (LCH), and plexiform neurofibromas. However, the ubiquitous nature of the BRAF/MAPK/MEK pathway in various physiological processes means that these treatments are not without their own side effects such as renal tubulopathies (causing hyponatraemia) and hyperglycaemia.Aim: T...